This study aimed to evaluate the effectiveness of a multicomponent intervention, including cognitive components, for improving health-related quality of life (HRQOL) in women with moderate to severe overactive bladder (OAB). The multicenter, randomized clinical trial involved 79 women aged 20 to 80 years who were recruited from four institutions in Japan. Participants were randomly assigned to either a four-week intervention or a waiting list control group. The primary outcome was the change in HRQOL total scores from baseline to week 13, with secondary outcomes including OAB symptom score and frequency volume chart.

Results showed that the multicomponent intervention significantly improved HRQOL, with the intervention group achieving a 23.9-point improvement compared to 11.3 points in the control group. This difference of 12.6 points was statistically significant (P<.001). The intervention also resulted in improvements in micturition frequency and urgency, but there was no significant change in the OAB symptom score. The study concludes that a multicomponent intervention, particularly with cognitive components, can effectively enhance HRQOL in women with moderate to severe OAB.

Reference: Funada S, Luo Y, Uozumi R, et al. Multicomponent Intervention for Overactive Bladder in Women: A Randomized Clinical Trial. JAMA Netw Open. 2024;7(3):e241784. doi: 10.1001/jamanetworkopen.2024.1784.